Technical Expertise

• Embedded Systems: FPGA, MCU, SOC

• High-speed Data Acquisition

• Real-time Processing

• Big Data Analysis

• User Interface Design

• Systems Integration

• ASIC Design

Domain-Specific Experience

• In Vivo Electrophysiology

• Microscopy, Optics, and Image Sensors

• Astronomy and Space Physics

• High-performance Scientific Computing

Services

• Custom R&D

• Technical Consulting

• Grant Writing and Support

LeafLabs can help you build tools to redefine your field

LeafLabs works with academic, government, and industry partners to build technology that pushes the boundaries of science and engineering.  We love the challenge of squeezing an order of magnitude more speed, data, resolution, etc. from an instrument to enable new discoveries and innovations.

Whether you need help optimizing a pre-existing design, interfacing with third-party components, or designing a novel system from the ground up, our team can help provide game-changing solutions specific to your domain.

Scientific Instrumentation Case Studies

Collaborators

• Ed Boyden, Synthetic Neurobiology Lab at MIT

• Hugh Herr, Biomechatronics Lab at MIT

• Ken Shepard, Bioelectronic Systems Lab at Columbia University

• Stephen Van Hooser, Neural Circuits Lab at Brandeis University

• Paola Arlotta, Department of Stem Cell & Regenerative Biology at Harvard

Publications

2018

• Brian D. Allen, Caroline Moore-Kochlacs, Jacob Gold Bernstein, Justin Kinney, Jorg Scholvin, Luis Seoane, Chris Chronopoulos, Charlie Lamantia, Suhasa B Kodandaramaiah, Max Tegmark, and Edward S Boyden (2018) Automated in vivo patch clamp evaluation of extracellular multielectrode array spike recording capability. Journal of Neurophysiology https://doi.org/10.1152/jn.00650.2017

• Jörg Scholvin, Anthony Zorzos, Justin Kinney, Jacob Bernstein, Caroline Moore-Kochlacs, Nancy Kopell, Clifton Fonstad and Edward S. Boyden. (2018) Scalable, Modular Three-Dimensional Silicon Microelectrode Assembly via Electroless Plating Micromachines 9:436; https://doi.org/10.3390/mi9090436

2017

• Quadrato G, Nguyen T, Macosko EZ, Sherwood JL, Min Yang S, Berger DR, Maria N, Scholvin J, Goldman M, Kinney JP, Boyden ES, Lichtman JW, Williams ZM, McCarroll SA, Arlotta P (2017) Cell diversity and network dynamics in photosensitive human brain organoids, Nature 545(7652):48-53. https://doi.org/10.1038/nature22047

2016

• Scholvin J, Kinney JP , Bernstein JG, Moore-Kochlacs C, Kopell N, Fonstad C, & Boyden ES (2016). Heterogeneous neural amplifier integration for scalable extracellular microelectrodes, Engineering in Medicine and Biology Society (EMBC), 2016 IEEE 38th Annual International Conference of the , DOI: 10.1109/EMBC.2016.7591309

• Scholvin J, Kinney JP , Bernstein JG, Moore-Kochlacs C, Kopell N, Fonstad C, & Boyden ES (2015). Close-Packed Silicon Microelectrodes for Scalable Spatially Oversampled Neural Recording, IEEE Transactions on Biomedical Engineering, 63(1):120-30. DOI:10.1109/TBME.2015.2406113.

2015

• Kinney JP, Bernstein JG, Meyer AJ, Barber JB, Bolivar M, Newbold B, Scholvin J, Moore-Kochlacs C, Wentz CT, Kopell NJ and Boyden ES (2015) A direct-to-drive neural data acquisition system. Front. Neural Circuits 9:46. DOI: 10.3389/fncir.2015.00046.